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FRANCISCO PELEGRI
PRINCIPAL INVESTIGATOR
Professor and Department Chair
Genetics and Medical Genetics
Francisco Pelegri obtained his B.S. in Genetics from the University of California-Berkeley in 1987 and his Ph.D. in Cellular and Molecular Biology from the Massachusetts Institute of Technology in 1994. He pursued postdoctoral research at the Max-Planck Institute for Developmental Biology in Tübingen, Germany, completing his fellowship in 1999.
He joined the University of Wisconsin–Madison in 1999, where he is currently Professor and has served as Chair of the Department of Genetics since 2020.
His research focuses on the analysis of cellular and developmental mechanisms involved in the vertebrate egg-to-embryo transition and early cell fate specification, with the broader goal of understanding the processes that drive early vertebrate development and the functional diversification of cell types. He is affiliated with the Cellular and Molecular Biology, Endocrinology–Reproductive Physiology, and Genetics programs.
His research fields span cell biology, computational, systems and synthetic biology, developmental biology, and zebrafish as a model system.
About Me.
Professor Pelegri’s research focuses on the cellular and molecular mechanisms that underlie the earliest stages of vertebrate development. His work uses the zebrafish (Danio rerio) as a powerful model system to investigate how maternal factors deposited in the egg control developmental events before and after activation of the zygotic genome at the mid-blastula transition. A central goal of his research is to identify and characterize genes that regulate key cell fate decisions, including germ line determination, dorsal axis formation, and germ layer specification. Because germ cell fate segregation in zebrafish is closely tied to the mechanics of cell division, his group also examines the genes and subcellular processes essential for cytokinesis.
Education
1994-1999
Postdoctoral Position
Max Planck Institute for Developmental Biology
1994
Ph.D. Medical Genetics
Massachusetts Institute of Technology
1983-1987
B.S. Genetics
University of California, Berkeley
